July 27th, 2017


Passive versus covalent conjugation of antibodies to gold nanoparticles

July 3rd, 2017

Antibodies can be attached to gold nanoparticles by a variety of methods. These include passive adsorption, covalent attachment to surface-functionalized nanoparticles, and attachment to nanoparticles which have been pre-coated with a binding reagent such as streptavidin, biotin or Protein A/G. Passive adsorption Passive adsorption relies primarily on hydrophobic attractions and electrostatic interactions between the antibody…