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InnovaCoat® GOLD – Carboxyl 40OD 40nm

InnovaCoat® GOLD nanoparticle

InnovaCoat® GOLD-Carboxyl nanoparticles are coated gold nanoparticles functionalized with carboxyl groups that allow the covalent conjugation of antibodies, using the water soluble carbodiimide crosslinker EDC.

The product enables the generation of highly stable covalent gold-antibody conjugates at R&D and manufacturing scales.

Unlike traditional EDC/NHS coupling used to activate carboxyl groups, InnovaCoat® GOLD-Carboxyl nanoparticles are optimized for single step EDC covalent coupling without signs of aggregation. This eliminates the need for EDC/NHS pre-activation and washing steps associated with traditional conjugations.

This process is also significantly faster than standard methods, with conjugates ready to use in less than 35 minutes.

InnovaCoat® GOLD carboxyl nanoparticles have a narrow size distribution, a uniform spherical shape and high batch-to-batch consistency.

Mean Diameter  36-44nm
SD  <4nm
CV%  <10%

Product details

Composition: 40nm carboxyl-gold 40 OD carboxyl gold nanoparticles web
Size: 40nm
Adsorption max: 530nm
OD: 40.0
Particles per ml: 36 x 1011
Volume: 1ml and 5ml
Buffer: 10mM EPPS pH 8.5

Please refer to our custom services for bulk orders or get in contact with us to know more about this product.

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Figure 1. Lateral Flow Assay of our 40nm InnovaCoat GOLD-Carboxyl gold nanoparticles conjugated with EDC (1 step) to a monoclonal anti-CRP antibody (mAb1) titrated against CRP in buffer compared to a 2 steps EDC/NHS reaction using a competitor’s 40nm carboxyl-gold. The 40nm InnovaCoat GOLD-Carboxyl conjugate shows a better sensitivity than the competitor, no aggregation is seen and requires only 35 minutes to make. Following the competitor’s instruction, their product required from 3 to 5 hours for the EDC/NHS activation and conjugation reaction and significant optimization to prevent aggregation.

 

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